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Mouse IGFBP-5, recombinant protein (Receptor Grade)
Insulin-like Growth Factor Binding Protein-5, mouse, recombinant Synonyms: IGF binding protein-5, Ibp5
Product Specifications Mouse IGFBP-5:
Mouse Insulin-like Growth Factor Binding Protein-5 (mIGFBP-5) is a 252 amino acid protein that is one of the six “classical†IGF binding proteins that play an important role in stabilizing and regulating the activity of IGFs in vivo. Mouse IGFBP-5 preferentially binds IGF-II and it also binds with high affinity to extracellular matrix components which protect it from proteolysis. Like human IGFBP-5, mouse IGFBP-5 has a nuclear targeting sequence.
References:
Kiefer M. et al. (1991) Biochem. Biophys. Res. Commun. 176, 219-225
Song, H. et al. (2000) J. Mol Endocrinol. 24, 43-51
Source:
Produced recombinantly in E.coli.
Purified by affinity and other chromatographic steps.
Purity:
> 90% (by SDS PAGE)
Molecular Weight:
29 kDa (non-glycosylated; five amino acid N-terminal extension)
Biological Activity:
Binds 125I-IGF-I in western ligand blot. Binding affinity for IGF-I - 0.2nM (Biosensor)
State and Appearance:
Lyophilized white powder dried from phosphate buffered saline and stored under dry nitrogen at a slight vacuum (-25 kPa).
Storage/Stability:
At least 2 years at 2 - 4°C (lyophilized)
This a GroPep Specification! ibt is authorized distributor of GroPep!
Rev2013-03
Datasheet for Mouse IGFBP-5, recombinant protein (Receptor Grade)