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Insulin-like Growth Factor Binding Proteins (IGFBP´s)
Human IGFBP-6, recombinant protein (Receptor Grade)
Insulin-like Growth Factor Binding Protein-6, human, recombinant Synonyms: IGF binding protein-6, Ibp
Product Specifications Human IGFBP-6:
Human Insulin-like Growth Factor Binding Protein-6 (rhIGFBP-6) is a 216 amino acid glycosylated protein that is one of the six 'classical' IGF binding proteins. These binding proteins have an important role in stabilizing and regulating the activity of IGFs in vivo. Human IGFBP-6 binds IGF-II with a 20-70 fold higher affinity than IGF-I. The major glycosylated protein species contains 216 amino acids, but a minor isoform with a 2 amino acid N-terminal extension is produced as a result of alternative processing by the CHO cells used for the rhIGFBP-6 production.
Link to Sequence.
Neumann GM et al (1998) Biochemistry 37, 6572-6585.
Zapf J (1995) Eur. J. Endocrinol. 132, 645-654.
Source: Produced recombinantly in mammalian cells. Purified by affinity and other chromatographic steps.
Purity: > 95% (as determined by HPLC)
Molecular weight:28,000 - 30,000 daltons (glycosylated). Confirmed by SDS-PAGE
Quantity: 20 Âµg
Appearance: Lyophilized white powder
Biological Activity: Single species detected by Western Ligand Blot
State:Dried from 10 mM HCl
Reconstitution: Reconstitute in 100 Âµl 10 mM HCl at a concentrationof 0.15 mg/ml. Aliquot, snap freeze and store at -80Â°C. Avoid freeze-thaw cycles.
Storage/Stability: At least 2 years at 2-4Â°C (lyophilized)
This a GroPep Specification! ibt is authorized distributor of GroPep!
Datasheet for Human IGFBP-6, recombinant protein (Receptor Grade)